New research indicates that people who come off popular weight-loss injections like semaglutide or tirzepatide tend to recover reduced body mass far faster than those who stop traditional lifestyle regimens.
Findings released in a prominent health publication points out that while obese people can lose a large proportion of their body weight while undergoing treatment, the weight comes back at an average rate of 0.8 kg per month once they quit.
"People buying such treatments should be informed of the risk of rapid rebound weight gain when the medication is stopped," cautioned researcher Dr. Susan Jebb.
That rate of recovery suggests a reversion to pre-treatment weight within about a year and a half.
Comparing Treatments
The research, which reviewed 37 of trials involving over 9,000 of patients, compared the effects of the injectable medications with other pills.
Researchers note that people who shed pounds through diet and exercise usually experience a less rapid weight regain—perhaps 100 grams monthly—after stopping.
The Reason for the Quick Regain
Doctors suggest the mechanism of the jabs is key to understanding the accelerated rebound.
These medications copy a natural hormone called glucagon-like peptide-1, which moderates feelings of fullness.
"Artificially providing the hormone levels far above than the body's typical production could lead to the body to generate a reduced amount of its endogenous GLP-1, and could reduce sensitivity to its actions," noted Dr. Adam Collins, a dietetics researcher.
"Discontinuation of this hormone supplement results in appetite is no longer kept in check, making binge eating much more probable."
A Chronic Issue?
Health authorities advise the jabs for people with weight-linked health risks, accompanied by prescribed lifestyle changes.
A number of clinicians say that, due to the significant potential of relapse, the treatment should be considered ongoing.
This opinion is echoed by pharmaceutical companies, who say that the findings "highlight the persistent character of excess weight," akin to managing diseases like diabetes.
Patient Accounts
Individuals who have come off the jabs report a intense resurgence of cravings.
"It felt as if a switch activating and I was suddenly ravenous," said an individual.
This difficulty is compounded if patients have not developed permanent lifestyle or habit modifications during therapy.
Widespread Adoption
Figures suggest that millions of people in the UK have used these injections in the last 12 months, with interest remaining high.
- Use is higher among women compared to males.
- The 40s and 50s demographic shows the highest level of interest.
- Many obtain the drugs through private prescriptions rather than public health services.
Ultimately, clinicians stress that while these medications are powerful tools for shedding pounds, they are not a magic cure and maintained weight loss hinges on combined behavioural changes.
